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4-PQBH
CAS No. 2243355-51-1
4-PQBH ( —— )
产品货号. M35557 CAS No. 2243355-51-1
4-PQBH 是一种有效的 Nur77 粘结剂 (KD=1.17 μM)。4-PQBH 通过 nur77 介导的内质网应激和自噬广泛诱导 caspase 不依赖的细胞质空泡化和凋亡。4-PQBH 可用于癌症研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称4-PQBH
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述4-PQBH 是一种有效的 Nur77 粘结剂 (KD=1.17 μM)。4-PQBH 通过 nur77 介导的内质网应激和自噬广泛诱导 caspase 不依赖的细胞质空泡化和凋亡。4-PQBH 可用于癌症研究。
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产品描述4-PQBH is a potent Nur77 binder (KD=1.17 μM). 4-PQBH extensively induces caspase-independent cytoplasmic vacuolization and paraptosis through Nur77-mediated ER stress and autophagy. 4-PQBH can be used for cancer research.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2243355-51-1
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分子量367.4
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分子式C22H17N5O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 25 mg/mL (68.05 mM; 超声助溶 )
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SMILESO=C(NN=CC=1C=CN=CC1)C2=CC=C(C=C2)NC=3C=CN=C4C=CC=CC43
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Baicun Li, et al. Discovery of a Nur77-mediated cytoplasmic vacuolation and paraptosis inducer (4-PQBH) for the treatment of hepatocellular carcinoma. Bioorg Chem. 2022 Apr;121:105651.?
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