AIMP2-DX2-IN-1 ( —— )

产品货号. M35543 CAS No. 848256-17-7

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

AIMP2-DX2-IN-1
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

AIMP2-DX2-IN-1 (Compound 35) 是一种有效的 AIMP2-DX2 抑制剂，IC50 值为 0.1063 μM。
产品描述

AIMP2-DX2-IN-1 (Compound 35) is a potent AIMP2-DX2 inhibitor with an IC50 of 0.1063 μM.
体外实验

AIMP2-DX2-IN-1 (Compound 35) (0-1 μM, 96 h) shows inhibitory activity against A549 and H460 cells without toxicity for normal cells.AIMP2-DX2-IN-1 showes very poor metabolic stability and good plasma stability in both human and mouse, and CYP inhibition need to be improved.Cell Viability Assay Cell Line:A549, H460 and WI-26 Concentration:0-1 μM Incubation Time:96 h Result:Showed inhibitory activities with EC50s of 0.690 ± 0.648 μM and 0.150 ± 0.062 μM against A549 and H460 cells, respectively. And is not active for WI-26.
体内实验

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同义词

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通路

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靶点

Other Targets
受体

Others
研究领域

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适应症

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1. Lee B, et al. Discovery of benzodioxane analogues as lead candidates of AIMP2-DX2 inhibitors. Bioorg Med Chem Lett. 2022 Jul 13;73:128889.?

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