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Chromenone 1
CAS No. 1639929-29-5
Chromenone 1 ( —— )
产品货号. M35539 CAS No. 1639929-29-5
Chromenone 1 是一种有效的成骨骨形态发生蛋白 (BMP) 增强剂。Chromenone 1 表现出独特的作用模式，因为它诱导了显著的、非激酶依赖的、负的 TGFβ 反馈，从而增强了核 BMP-Smad 信号输出。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥647 | 有现货 |
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| 10MG | ￥1026 | 有现货 |
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| 25MG | ￥1609 | 有现货 |
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| 50MG | ￥2213 | 有现货 |
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| 100MG | ￥2898 | 有现货 |
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| 200MG | ￥3897 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥656 | 有现货 |
|
生物学信息
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产品名称Chromenone 1
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Chromenone 1 是一种有效的成骨骨形态发生蛋白 (BMP) 增强剂。Chromenone 1 表现出独特的作用模式，因为它诱导了显著的、非激酶依赖的、负的 TGFβ 反馈，从而增强了核 BMP-Smad 信号输出。
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产品描述Chromenone 1 is a potent osteogenic bone morphogenetic protein (BMP) potentiator. Chromenone 1 exhibits a unique mode of action as it induces a pronounced, kinase-independent, negative TGFβ feedback that enhances nuclear BMP-Smad signaling outputs.
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体外实验Chromenone 1 rescues DMH-1-induced cardiogenesis (IC50=0.2 μM) and efficiently stimulates BMP-dependent osteogenesis from C2C12 myoblasts.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体TGF-beta/Smad
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研究领域——
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适应症——
化学信息
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CAS Number1639929-29-5
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分子量357.29
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分子式C18H10F3N3O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (279.88 mM; 超声助溶 )
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SMILESO=C1C(=C(OC=2C1=CC=CC2)N3C=NC=N3)C4=CC=C(C(F)(F)F)C=C4
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Wesseler F, et al. Probing Embryonic Development Enables the Discovery of Unique Small-Molecule Bone Morphogenetic Protein Potentiators. J Med Chem. 2022;65(5):3978-3990. ?
产品手册
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