Quinupramine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Quinupramine 是一种口服有效的抗抑郁剂。Quinupramine 可透过中枢神经系统，影响神经传递的一些过程。Quinupramine 的抗抑郁活性与中枢血清素系统有关，但与 β- 肾上腺素能系统无关。

Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system.

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Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat.Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations.Animal Model:Sprague-Dawley rats (Male, 220-270 g)Dosage:10 mg/kg Administration:PO, twice daily for 10 days Result:Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor

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31721-17-2

304.43

C21H24N2

>98% (HPLC)

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C=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)C4CN5CCC4CC5

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(-20℃)

With Ice Pack

≥ 2 years