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Quinupramine
CAS No. 31721-17-2
Quinupramine ( —— )
产品货号. M35460 CAS No. 31721-17-2
Quinupramine 是一种口服有效的抗抑郁剂。Quinupramine 可透过中枢神经系统，影响神经传递的一些过程。Quinupramine 的抗抑郁活性与中枢血清素系统有关，但与 β- 肾上腺素能系统无关。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥7059 | 有现货 |
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| 25MG | ￥13857 | 有现货 |
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| 50MG | ￥17949 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Quinupramine
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Quinupramine 是一种口服有效的抗抑郁剂。Quinupramine 可透过中枢神经系统，影响神经传递的一些过程。Quinupramine 的抗抑郁活性与中枢血清素系统有关，但与 β- 肾上腺素能系统无关。
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产品描述Quinupramine is an orally active antidepressant. Quinupramine can penetrate into the CNS and affect some of the processes of neurotransmission. The antidepressant activity of quinupramine is associated with the central serotonin system, but not with the β-adrenergic system.
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体外实验——
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体内实验Quinupramine (10 mg/kg, PO, twice daily for 10 days) causes a down-regulation of serotonin S2 receptors in the frontal cortex of the rat.Quinupramine-EVA matrix containing a permeation enhancer can be a good transdermal delivery system for providing sustained plasma concentrations.Animal Model:Sprague-Dawley rats (Male, 220-270 g)Dosage:10 mg/kg Administration:PO, twice daily for 10 days Result:Caused a down-requlation of serotonin S2 receptors in the frontal cortex of the rat, did not alter the binding populations of Q-adrenergic, muscarinic cholinergic and a2-adrenergic receptors in the rat brain.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number31721-17-2
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分子量304.43
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分子式C21H24N2
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纯度>98% (HPLC)
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溶解度——
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SMILESC=1C=CC2=C(C1)N(C=3C=CC=CC3CC2)C4CN5CCC4CC5
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Sakamoto H, et al. Effects of quinupramine on the central monoamine uptake systems and involvement of pharmacokinetics in its pharmacological activities. Jpn J Pharmacol. 1987;45(2):169-175.?
产品手册
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