PI3K/Akt/mTOR-IN-2 ( —— )

产品货号. M35442 CAS No. 2757804-89-8

PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用，并对 MDA-MB-231 细胞具有选择性，IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥749	有现货
10MG	￥1302	有现货
25MG	￥2669	有现货
50MG	￥3953	有现货
100MG	￥5337	有现货
500MG	￥11070	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥824	有现货

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生物学信息

产品名称

PI3K/Akt/mTOR-IN-2
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

PI3K/Akt/mTOR-IN-2 是一种有效的 PI3K/AKT/mTOR 抑制剂。PI3K/Akt/mTOR-IN-2 具有抗癌作用，并对 MDA-MB-231 细胞具有选择性，IC50 为 2.29 μM。PI3K/Akt/mTOR-IN-2 可诱导癌细胞周期阻滞和细胞凋亡 (apoptosis)。
产品描述

PI3K/Akt/mTOR-IN-2 is a PI3K/AKT/mTOR pathway inhibitor. PI3K/Akt/mTOR-IN-2 possess anti-cancer effects and selectivity against MDA-MB-231 cells with IC50 value of 2.29 μM. PI3K/Akt/mTOR-IN-2 can induce cancer cell cycle arrest and apoptosis.
体外实验

PI3K/Akt/mTOR-IN-2 (compound 23) (0.5 - 100 μM; 72 hours) exhibits effective anti-cancer activity with IC50s of 2.29 - 24.63 μM, of which, IC50 in MDA-MB-231 is 2.29 μM.PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24 hours) induces growth inhibition of MDA-MB-231 cells by cell cycle arrest at G0/G1.PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24, 48 and 72 hours) induces apoptosis in MDA-MB-231 cells with both dose- and time-dependent manners.PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 48 hours) increases the expression of Bax, and decreases the expression of Bcl-2 in MDA-MB-231 cells.PI3K/Akt/mTOR-IN-2 (1 μM, 2 μM and 4 μM; 24 hours) induces mitochondria-dependent apoptosis in MDA-MB-231 cells through disruption of MMP, accumulation of ROS, depletion of GSH and elevation of intracellular Ca2+.]Cell Proliferation Assay Cell Line:PC3, BGC-823, A549, MCF-7, MDA-MB-231 cells and MCF-10A cells Concentration:0.5 - 100 μMIncubation Time:72 hoursResult:Exhibited effective anti-cancer activity with IC50s of 2.29 - 24.63 μM, of which, IC50 in MDA-MB-231 was 2.29 μM.Cell Cycle Analysis Cell Line:MDA-MB-231 Concentration:1 μM, 2 μM and 4 μM Incubation Time:24 hours Result:Induced growth inhibition of MDA-MB-231 cells by cell cycle arrest at G0/G1. Apoptosis Analysis Cell Line:MDA-MB-231 Concentration:1 μM, 2 μM and 4 μM Incubation Time:24, 48 and 72 hours Result:Induced apoptosis in MDA-MB-231 cells with both dose- and time-dependent manners.Western Blot Analysis Cell Line:MDA-MB-231 Concentration:1 μM, 2 μM and 4 μM Incubation Time:48 hours Result:Increased the expression of Bax, and decreased the expression of Bcl-2
体内实验

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同义词

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通路

PI3K/Akt/mTOR signaling
靶点

mTOR
受体

mTOR | Akt | Apoptosis | PI3K
研究领域

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适应症

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化学信息

CAS Number

2757804-89-8
分子量

285.29
分子式

C17H13F2NO
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (350.52 mM; )
SMILES

Fc1cc(F)cc(c1)C1OCCc2c1[nH]c1ccccc21
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Qin J, Sun X, Ma Y, et al. Design, synthesis and biological evaluation of novel 1,3,4,9-tetrahydropyrano[3,4-b]indoles as potential treatment of triple negative breast cancer by suppressing PI3K/AKT/mTOR pathway [published online ahead of print, 2021 Dec ?

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