PBRM1-BD2-IN-5

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PBRM1-BD2-IN-5 是一种有效的 PBRM1 Bromodomain 抑制剂，对 PBRM1-BD2 和 PBRM1-BD5 的 Kd 分别为 1.5 μM 和 3.9 μM，对 PBRM1-BD2 的 IC50 为 0.26 μM。PBRM1-BD2-IN-5 减少细胞裂解物中 PBAF 复合体全长 PBRM1 与乙酰化组蛋白肽的结合。PBRM1-BD2-IN-5 可用于抗癌研究。

PBRM1-BD2-IN-5 is a potent PBRM1 Bromodomain inhibitor with Kd values of 1.5 μM and 3.9 μM for PBRM1-BD2 and PBRM1-BD5, respectively, and an IC50 value of 0.26 μM for PBRM1-BD2. PBRM1-BD2-IN-5 reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptide. PBRM1-BD2-IN-5 can be used to research anticancer.

PBRM1-BD2-IN-5 (compound 16) (0-10 μM; 5 days) inhibits PBRM1-expressed LNCaP cells, and reduces the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides.Cell Viability Assay Cell Line:LNCaP cells expressing lentiviral shPBRM1 Concentration:0, 0.1, 1 and 10 μM Incubation Time:5 days Result:Exhibited a more significant effect on LNCaP viability in cells with native PBRM1 levels than in cells with PBRM1 knockdown.Reduced the binding of full-length PBRM1 within the PBAF complex in cell lysates to acetylated histone peptides.

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Chromatin/Epigenetic

Epigenetic Reader Domain

Epigenetic Reader Domain

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2819989-61-0

272.73

C15H13ClN2O

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (366.66 mM; 超声助溶 )

O=C1C=2C(NC(N1)C3=CC(C)=CC=C3)=CC=CC2Cl

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(-20℃)

With Ice Pack

≥ 2 years