PBRM1-BD2-IN-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PBRM1-BD2-IN-2 是一种选择性和细胞活性的 PBRM1 溴化域抑制剂。PBRM1-BD2-IN-2 对 PBRM1-BD2 具有结合亲和力和抑制活性， Kd 和 IC50 值分别为 9.3 μM 和 1.0 μM。PBRM1-BD2-IN-2 可用于癌症的研究。

PBRM1-BD2-IN-2 is a selective and cell-activepolybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer.

PBRM1-BD2-IN-2 (0, 0.1, 1, and 10 μM; 5 days) selectively inhibit growth of a PBRM1-dependent prostate cancer cell line.PBRM1-BD2-IN-2 has binding affinity for PBRM1-BD2, PBRM1-BD5, SMARCA2B amd SMARCA4 with Kd values of 9.3 μM, 10.1 μM, 18.4 μM and 69 μM, respectively.PBRM1-BD2-IN-2 has inhibitory activity for PBRM1-BD2 with IC50 value of 1.0 μM.Cell Viability Assay Cell Line:Human prostate cell lines LNCaP, PC3, and RWPE-1Concentration:0, 0.1, 1, and 10 μM Incubation Time:5 days Result:Inhibited LNCaP growth at higher concentrations.

——

——

Chromatin/Epigenetic

Epigenetic Reader Domain

Epigenetic Reader Domain

——

——

2819989-57-4

311.14

C14H9Cl2FN2O

>98% (HPLC)

——

O=C1C=2C(NC(N1)C3=C(Cl)C=CC=C3F)=CC=CC2Cl

——

(-20℃)

With Ice Pack

≥ 2 years