TDI-011536

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。

TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.

Cell Proliferation Assay Cell Line:human retinal organoids Concentration:3 μM Incubation Time:24 h, 5 days Result:Supressed Yap phosphorylation and promoted Müller glia proliferation.

Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).Dosage:200 mg/kg Administration:Intraperitoneal injections; once.Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.Animal Model:Male 8-week-old mice (cryolesion model).Dosage:100 mg/kg Administration:Intraperitoneal injections; once daily for 2 or 3 days.Result:Promoted cardiomyocytes proliferation.

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Others

Other Targets

Others

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2687970-96-1

364.42

C19H16N4O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 125 mg/mL (343.01 mM; 超声助溶 )

OCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years