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TDI-011536
CAS No. 2687970-96-1
TDI-011536 ( —— )
产品货号. M35339 CAS No. 2687970-96-1
TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥511 | 有现货 |
|
| 10MG | ￥787 | 有现货 |
|
| 25MG | ￥1609 | 有现货 |
|
| 50MG | ￥2623 | 有现货 |
|
| 100MG | ￥3825 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称TDI-011536
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述TDI-011536 是一种有效的 Lats 激酶抑制剂，能中断 Hippo-Yap 的信号传导，并可启动受损心肌细胞的增殖。TDI-011536 可用于研究器官的保护和再生。
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产品描述TDI-011536 is a potent Lats kinase inhibitor, interrupts Hippo-Yap signaling and initiates the proliferation of lesioned heartmuscle cells. TDI-011536 can be used in studies of organ conservation and regeneration.
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体外实验Cell Proliferation Assay Cell Line:human retinal organoids Concentration:3 μM Incubation Time:24 h, 5 days Result:Supressed Yap phosphorylation and promoted Müller glia proliferation.
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体内实验Animal Model:Living mice (immunoblot analysis of the heart, liver, and skin immediately after injection).Dosage:200 mg/kg Administration:Intraperitoneal injections; once.Result:Reduced the amount of pYap for at least 4 h after injection in all three organs and the levels returned to control values within a day.Animal Model:Male 8-week-old mice (cryolesion model).Dosage:100 mg/kg Administration:Intraperitoneal injections; once daily for 2 or 3 days.Result:Promoted cardiomyocytes proliferation.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number2687970-96-1
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分子量364.42
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分子式C19H16N4O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (343.01 mM; 超声助溶 )
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SMILESOCc1cs\c(=N/C(=O)c2c[nH]c3ncccc23)n1Cc1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Kastan NR, et al. Development of an improved inhibitor of Lats kinases to promote regeneration of mammalian organs. Proc Natl Acad Sci U S A. 2022 Jul 12;119(28):e2206113119. ?
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