021-51111890
购物车（）
sales@molnova.cn
SOD1-Derlin-1 inhibitor 56-59
CAS No. 2170170-27-9
SOD1-Derlin-1 inhibitor 56-59 ( —— )
产品货号. M35329 CAS No. 2170170-27-9
SOD1-Derlin-1 inhibitor-2 (compound 56-59) 是 SOD1-Derlin-1 相互作用的抑制剂。SOD1-Derlin-1 inhibitor-2 减弱 Derlin-1 和 SOD1mut 之间的相互作用。SOD1-Derlin-1 inhibitor-2 可用于肌萎缩侧索硬化症 (ALS) 的研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥331 | 有现货 |
|
| 10MG | ￥503 | 有现货 |
|
| 25MG | ￥1004 | 有现货 |
|
| 50MG | ￥1479 | 有现货 |
|
| 100MG | ￥2178 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥366 | 有现货 |
|
生物学信息
-
产品名称SOD1-Derlin-1 inhibitor 56-59
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述SOD1-Derlin-1 inhibitor-2 (compound 56-59) 是 SOD1-Derlin-1 相互作用的抑制剂。SOD1-Derlin-1 inhibitor-2 减弱 Derlin-1 和 SOD1mut 之间的相互作用。SOD1-Derlin-1 inhibitor-2 可用于肌萎缩侧索硬化症 (ALS) 的研究。
-
产品描述SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS).
-
体外实验——
-
体内实验Animal Model:ALS model C57BL/6 mice Dosage:3?mM, flow rate 0.15?μL/h Administration:intracerebroventrical injection Result:Had significantly delayed onset, by a median of 4.5 weeks (14.5% improvement) and prolonged survival, by a median of 5 weeks (14.2% improvement).
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Others
-
研究领域——
-
适应症——
化学信息
-
CAS Number2170170-27-9
-
分子量386.47
-
分子式C22H18N4OS
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (129.38 mM; 超声助溶 (<60°C)
-
SMILESNc1c(sc2nc(ccc12)-c1cccnc1)C(=O)N(CC=C)c1ccccc1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.?
产品手册
关联产品
-
(3β,20S,22Z,25R)-26-...
(3β,20S,22Z,25R)-26-(β-D-Glucopyranosyloxy)-20-hydroxyfurosta-5,22-dien-3-yl O-6-deoxy-α-L-mannopyranosyl-(1→2)-O-[β-D-glucopyranosyl-(1→4)]-β-D-glucopyranoside
-
Tormentic acid
Tormentic Acid是一种天然产物。它具有抗癌、抗炎、抗动脉粥样硬化、抗异常疼痛和保肝特性。
-
Isosalipurposide
Isosalipurposide, a chalcone compound, exerts a cytoprotective effect against oxidative injury via Nrf2 activation.
