Ziftomenib

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Ziftomenib (KO-539) 是一种具有口服活性的 menin-MLL 相互作用的抑制剂，具有抗肿瘤活性 (WO2017161028A1, compound 151)。

Ziftomenib (KO-539) is an orally active menin-MLL interaction inhibitor with antitumor activities (WO2017161028A1, compound 151).

The mixed-lineage leukemia (MLL) protein is a histone methyltransferase critical for the epigenetic regulation of gene transcription. Many acute leukemias, including acute myeloblastic leukemia (AML), acute lymphoblastic leukemia (ALL) and mixed-lineage leukemia (MLL), are characterized by the presence of chimeric MLL fusion proteins that result from chromosomal translocations of the MLL gene located at chromosome 11, band q23 (11q23). MLL fusion proteins lack the original histone methyltransferase activity of the C-terminus of MLL and gain the ability to regulate transcription of numerous oncogenes, including HOX and MEIS1, resulting in increased cell proliferation and decreased cell differentiation, ultimately leading to leukemogenesis.

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Others

Other Targets

Histone Methyltransferase

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2134675-36-6

717.871

C33H42F3N9O2S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (139.30 mM; 超声助溶 )

CNc1nc(NC2CCN(Cc3ccc4n(C[C@H](C)N5CCN(CC5)S(C)(=O)=O)c(cc4c3C)C#N)CC2)c2cc(CC(F)(F)F)sc2n1

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(-20℃)

With Ice Pack

≥ 2 years