YNT-185 ( —— )

产品货号. M35102 CAS No. 1804978-81-1

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

YNT-185
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

YNT-185 是一中非肽类的，选择性食欲素 2 型受体 (OX2R) 激动剂，对 OX2R 和 OX1R 的 EC50 分别为 0.028 和 2.75 μM。YNT-185 改善小鼠模型的发作性瘫痪症状。
产品描述

YNT-185 is a nonpeptide, selective orexin type-2 receptor (OX2R) agonist, with EC50s of 0.028 and 2.75 μM for OX2R and OX1R, respectively. YNT-185 ameliorates narcolepsy-cataplexy symptoms in mouse models.
体外实验

——
体内实验

YNT-185 (20-40 mg/kg; i.p.) increases wakefulness in mice.YNT-185 (300 nmol; i.c.v.) significantly increases wake time for 3 hours in a dose-dependent manner, accompanied by a decrease in NREM sleep time, in wild-type mice but not in OXRDKO mice.Animal Model:Male wild-type C57BL/6J mice Dosage:20, 40 mg/kg Administration:I.p.Result:Wake time was also significantly increased.
同义词

——
通路

Others
靶点

Other Targets
受体

OX Receptor
研究领域

——
适应症

——

CAS Number

1804978-81-1
分子量

615.74
分子式

C33H37N5O5S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (162.41 mM; 超声助溶 )
SMILES

S(NC1=CC(NCCNC(=O)C2=C(N(C)C)C=CC=C2)=CC=C1)(=O)(=O)C3=C(OC)C=CC(=C3)C4=CC(C(N(C)C)=O)=CC=C4
化学全称

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1. Nagahara T, et al. Design and Synthesis of Non-Peptide, Selective Orexin Receptor 2 Agonists. J Med Chem. 2015;58(20):7931-7937.?

计算器

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