F13714 fumarate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

F13714 fumarate 是一种选择性 5-HT1A 受体偏向激动剂，在慢性轻度应激小鼠模型中单次给药后具有抗抑郁样特性。

F13714 fumarate, a selective 5-HT1A receptor biased agonist, shows antidepressant-like properties after a single administration in the mouse model of chronic mild stress.

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In UCMS mice, a single administration of F13714 (4–16 mg/kg) is sufficient to robustly normalize depressive-like behavior in theforced swim test (FST). F13714 rescues cortical and hippocampal deficits in p-ERK1/2 levels but does not influence the p-CREB levels. F13714 decreases the immobility in mice at the doses 2 and 4 mg/kg by 30.3% and 19.5%.F13714 (0.5-2 mg/kg) given alone significantly and dose-dependently decreases rectal body temperature in mice during a 2-h measurement. F13714 (2.5 mg/kg) possess antidepressant-and anxiolytic-like properties in na?ve rats.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor

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208109-39-1

538.97

C25H29ClF2N4O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (463.85 mM; 超声助溶 )

C(=C/C(O)=O)\C(O)=O.C(=O)(N1CCC(CNCC=2N=C(NC)C(C)=CC2)(F)CC1)C3=CC(Cl)=C(F)C=C3

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(-20℃)

With Ice Pack

≥ 2 years