SSK1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SSK1，是一种衰老特异性杀伤化合物，是一种 β-galactosidase 靶向前体，可减轻炎症。SSK1 被溶酶体 β-galactosidase 激活，并通过激活 p38 MAPK 和诱导细胞凋亡 (apoptosis) 选择性杀死衰老细胞。

SSK1, a senescence-specific killing compound, is a β-galactosidase-targeted proagent attenuates inflammation. SSK1 is activated by lysosomal β-galactosidase and selectively killed senescent cells through the activation of p38 MAPK and induction of apoptosis.

Cell Proliferation Assay Cell Line:Primary mouse fibroblasts,Concentration:0.5?μM,Incubation Time:12 hours, 24 hours, 36 hours, 48 hours, 72 hours Result:Both p38 MAPK and MKK3/MKK6 were activated by phosphorylation in senescent cells.

Animal Model:Mice (3-6-month-old) were subjected to transtracheal injection of Bleomycin Dosage:0.5 mg/kg Administration:Intraperitoneally injection; two days every week; for four weeks Result:SSK1 significantly reduced the percentage of SA-β-gal-positive cells in lung by 3.8-fold compared with t hat in vehicle-treated lung-injured mice

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MAPK/ERK Signaling

p38 MAPK

p38 MAPK

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2629250-69-5

788.61

C31H34F2N4O18

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 200 mg/mL (253.61 mM; 超声助溶 )

[H][C@]1(O[C@H](CO)[C@@H](O)C1(F)F)n1ccc(NC(=O)OCc2ccc(O[C@@H]3O[C@H](COC(C)=O)[C@H](OC(C)=O)[C@H](OC(C)=O)[C@H]3OC(C)=O)c(c2)[N+]([O-])=O)nc1=O

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(-20℃)

With Ice Pack

≥ 2 years