Cysmethynil

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Cysmethynil 是一种 Icmt 抑制剂（IC50 = 2.4 μM）。Cysmethynil 抑制 RAS 膜结合和EGF的信号转导。Cysmethynil 将细胞周期阻滞在 G1 期，诱导细胞自噬。Cysmethynil 抑制 PC3 细胞增殖，与 Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A) 有协同作用。Cysmethynil 具有抗肿瘤作用，可用于实体瘤 (例如前列腺癌等) 研究。

Cysmethynil is an Icmt inhibitor(IC50 = 2.4 μM). Cysmethynil inhibites RAS membrane binding and EGF signal transduction. Cysmethynil prevents the cells in the G1 phase and induces autophagy. Cysmethynil inhibits PC3 cells proliferation, has synergistic effect with Paclitaxel (HY-B0015) and Doxorubicin (HY-15142A). Cysmethynil has anti-tumor effects and can be used for solid tumor (such as prostate cancer et al.) research.

Cell Viability AssayCell Line:PC3 cells Concentration:20-30 μM cysmethynil Incubation Time:1-6 days Result:Resulted in a dose- and time-dependent reduction in the number of viable PC3 cells.

Animal Model:6 week-old SCID mice with SiHa cells in the mice flank Dosage:20 mg/kg (single; combination with Paclitaxel or Doxorubicin)Administration:intraperitoneal injection; three times a week; 2 weeks Result: Decreased in tumor size when treated with Cys alone, or Cysmethynil+Paclitaxel(HY-B0015)/Cysmethynil+ Doxorubicin(HY-15142A) .Animal Model:SCID mice with PC3 cells in a xenograft model Dosage:0.1 mg/g or 0.2 mg/g Cysmethynil Administration:intraperitoneal injection; every 48 h; 28 days Result:Decreased in tumor size when treated with both doses of cysmethynil.

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Autophagy

Autophagy

Autophagy | Ras

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851636-83-4

376.53

C25H32N2O

>98% (HPLC)

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O=C(N)CC1=CN(C2=CC=C(C=C21)C=3C=CC=C(C3)C)CCCCCCCC

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(-20℃)

With Ice Pack

≥ 2 years