N-Desmethyl Sildenafil
CAS No. 139755-82-1
N-Desmethyl Sildenafil ( —— )
产品货号. M34815 CAS No. 139755-82-1
N-Desmethyl Sildenafil (Desmethylsildenafil) 是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ¥540 | 有现货 |
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| 10MG | ¥901 | 有现货 |
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| 25MG | ¥1758 | 有现货 |
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| 50MG | ¥2604 | 有现货 |
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| 100MG | ¥3528 | 有现货 |
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| 200MG | ¥4905 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
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| 1 mL x 10 mM in DMSO | ¥565 | 有现货 |
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生物学信息
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产品名称N-Desmethyl Sildenafil
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述N-Desmethyl Sildenafil (Desmethylsildenafil) 是 Sildenafil 的主要代谢物。Sildenafil 是一种有效的 5 型磷酸二酯酶 (PDE5) 抑制剂。
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产品描述N-Desmethyl Sildenafil (Desmethylsildenafil) is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor.
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体外实验N-Desmethyl Sildenafil increases the amplitude of electroretinogram (ERG) recorded from the dark-adapted isolated rat retina, most probably through the enhancement of the photoreceptor cell response. The formation of N-Desmethyl Sildenafil is examined using CYP3A supersomes co-expressing human P450 oxidoreductase and cytochrome b5. N-Desmethyl Sildenafil is catalyzed by CYP3A4, CYP3A5, and to a lesser extent by CYP3A7.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体Drug Metabolite
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研究领域——
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适应症——
化学信息
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CAS Number139755-82-1
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分子量460.55
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分子式C21H28N6O4S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 250 mg/mL (542.83 mM; 超声助溶 )
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SMILESCCCc1nn(C)c2c1[nH]c(nc2=O)-c1cc(ccc1OCC)S(=O)(=O)N1CCNCC1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Corticotropin-releas...
Corticotropin-releasing factor human (Human CRF; Human corticotropin-releasing factor) is an immunomodulatory neuropeptide that acts to release ACTH from the anterior pituitary and stimulates the sympathetic nervous system and adrenal medulla. Functions by reducing hyperpolarizations. Acts as a functional antagonist of inflammatory mediators.
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Protoescigenin
原escigenin是一种天然产物。
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Pseudo RACK1
Activator of protein kinase C; attached to cell permeabilization Antennapedia domain vector peptide. Consists of peptide derived from the C2 domain of PKC β linked by a disulfide bridge to the Antennapedia domain vector peptide. The Antennapedia peptide is actively taken up by intact cells, at 4 or 37°C, ensuring rapid and effective uptake of the activator peptide. Once inside the cell, the disulfide bonds are subjected to reduction in the cytoplasm leading to release of the activator peptide.
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