PRGL493

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PRGL493 是一种高效、选择性的长链酰基辅酶 a 合成酶 4 (ACSL4) 抑制剂。PRGL493 在乳腺和前列腺细胞及动物模型中均可阻断细胞增殖和肿瘤生长。PRGL493 用于癌症研究。

PRGL493 is a potent and selective long-chain acyl-CoA synthetase 4 (ACSL4) inhibitor. PRGL493 blocks cell proliferation and tumor growth in both breast and prostate cellular and animal models. PRGL493 is used for cancer research.

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Animal Model:MDA-MB-231 or PC-3 cell suspensions mixed with Matrigel Matrix in a 3/1 dilution are injected into the right fank of NLAE:NIH(S)Fox1nu mice, aged 7-8?weeks Dosage:250?μg/kg Administration: Intraperitoneal?injection; 250?μg/kg; 43 and 34 consecutive days Result:Inhibited tumor growth in vivo models

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Others

Other Targets

Others

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2479378-45-3

451.48

C25H21N7O2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 5 mg/mL (11.07 mM; 超声助溶 (<60°C)

CC(=O)NC1=NC(N2C(Nc3ccccc23)=N1)c1cn(nc1-c1ccc(C)o1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years