Osemozotan HCl

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Osemozotan hydrochloride (MKC242) 是选择性的 5-HT1A 受体激动剂。Osemozotan hydrochloride 减少在小鼠体内 MAMP 诱导的 c-Fos 阳性细胞数量。Osemozotan hydrochloride 可用于抑郁症的研究。

Osemozotan hydrochloride (MKC242) is a selective 5-HT1A receptor agonist. Osemozotan hydrochloride decreases the number of c-Fos-positive cells caused by MAMP in mice. Osemozotan hydrochloride can be used for the research of depressive disorder.

——

Osemozotan hydrochloride (1 mg/kg; i.p.; 20 min after picrotoxin treatment) ameliorates picrotoxin-induced decrease in female preference with the combination of (+)-SKF-10,047.Osemozotan hydrochloride (1 mg/kg; i.p.; once) decreases the number of c-Fos-positive cells caused by MAMP.Animal Model:Female CD-1 mice with picrotoxin-induced decrease in female preferenceDosage:1 mg/kg Administration:Intraperitoneal injection; 1 mg/kg; 20 min after picrotoxin treatment Result:Ameliorated the picrotoxin-induced decrease in the female preference by co-administration WITH (+)-SKF-10,047 (5 mg/kg). Showed no effect on the picrotoxin-induced decrease in the female preference when treated alone.Animal Model:ICR mice with MAMP injection Dosage:1 mg/kg Administration:Intraperitoneal injection; 1 mg/kg; once Result:Significantly decreased the number of c-Fos-positive cells induced by MAMP in the medial prefrontal cortex and striatum, but did not change the number of c-Fos-positive cells.

——

GPCR/G Protein

5-HT Receptor

5-HT Receptor

——

——

137275-80-0

379.84

C19H22ClNO5

>98% (HPLC)

——

O(CCCNC[C@@H]1OC=2C(OC1)=CC=CC2)C=3C=C4C(=CC3)OCO4.Cl

——

(-20℃)

With Ice Pack

≥ 2 years