IDX184

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

IDX184 是一种有效的，具有口服活性的 HCV 复制抑制剂。IDX184 有效抑制 HCV 聚合酶 (IC50=0.31 μM，Ki=52.3 nM)。

IDX184 is a potent and orally bioavailable inhibitor of HCV replication. IDX184 potently inhibits HCV polymerase (IC50=0.31 μM, Ki=52.3 nM).

IDX184 is a liver-targeted prodrug of the nucleotide 2′-MeG-MP. IDX184 is a liver-targeted nucleotide polymerase inhibitor of hepatitis C virus.IDX184 is a second generation, orally bioavailable nucleotide prodrug designed to provide increased anti-HCV efficacy and safety versus the parent nucleoside. In HCV replicon testing, IDX184 is the most potent inhibitor (EC50=0.3-0.45 μM) compared to any of the 2’ or 4’ modified nucleosides (EC50=4-6 μM) and is also highly inhibitory in the JFH-1 infectious system (EC50=0.06-0.11 μM). IDX184 is not toxic (CC50>100μM) in any tested cell line.

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Others

Other Targets

HCV Protease

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1036915-08-8

626.62

C25H35N6O9PS

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (398.97 mM; 超声助溶 )

C[C@]1(O)[C@H](N2C3=C(N=C2)C(=O)N=C(N)N3)O[C@H](COP(NCC4=CC=CC=C4)(OCCSC(C(CO)(C)C)=O)=O)[C@H]1O

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(-20℃)

With Ice Pack

≥ 2 years