TC LPA5 4

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TC LPA5 4 是一种特异性非脂质 LPA5 (GPR92) 拮抗剂。TC LPA5 4 抑制 LPA 诱导的离体人血小板 (LPA5-RH7777细胞系) 聚集，IC50 为 800 nM。TC LPA5 4 对 LPA5 的选择性超过 80 个其他筛选活性分子靶点。TC LPA5 4 抑制甲状腺癌细胞的增殖和迁移。

TC LPA5 4 is a LPA5 (GPR92)-specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA5-RH7777 cell line) with an IC50 of 800 nM. TC LPA5 4 displays selectivity for LPA5 over 80 other screened agent targets. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells.

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Animal Model:BALB/C nu/nu mice, aged 4 5 weeks (CGTH-W3 xenografts) Dosage:10 mg/kg Administration:Intraperitoneal injection; 5 days/week for 2 weeks Result:Significantly inhibits CGTH-W3 xenograft growth with inhibitory rates of 46.7%.

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GPCR/G Protein

LPA Receptor

LPA Receptor

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1393814-38-4

410.89

C23H23ClN2O3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 62.5 mg/mL (152.11 mM; 超声助溶 )

C(O)(=O)C=1C=C(N(N1)C2=CC(OC)=CC=C2)C3=CC(Cl)=C(C=C3)C4CCCCC4

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(-20℃)

With Ice Pack

≥ 2 years