Quipazine dimaleate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Quipazine dimaleate 是 5-HT 的激动剂，取代大鼠内皮层中 5-HT3R 的 [3H]GR65630 的 Ki 值为 1.4 nM。Quipazine dimaleate 对 SARS-CoV-2 具有抗病毒活性，EC50 值为 31.64 μM。Quipazine dimaleate 在外周模型中表现为 5-HT3R 的拮抗剂，可用于神经疾病研究。

Quipazine dimaleate is a 5-HT agonist with a Ki value of 1.4 nM for displaces [3H]GR65630 from 5-HT3R in rat. Quipazine dimaleate shows antiviral activity against SARS-CoV-2 with an EC50 of 31.64 μM. Quipazine dimaleate behaves as a 5-HT3R antagonist in peripheral models. Quipazine dimaleate can be used for neurological disease research.

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Animal Model:Male and female Wistar rats feed with different sources of the three macronutrients (Group 1: casein, corn starch, safflower oil. Group 2: egg protein, corn starch/sucrose, lard. Group S: casein hydrolysate, maltose dextrin, butter.)Dosage:2.5, 5 and 7.5 mg/kg Administration:Intraperitoneal injection; 2.5, 5 and 7.5 mg/kg, one dose for once Result:Increased water intake and food intake of male rats from Group S, and reduced food intake of female rats from Group 1 and Group 2s at 2h post-injection. Reduced food intake in female rats from Group 2, reduced protein intake in female rats from Group 1.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor

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150323-78-7

445.42

C21H23N3O8

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 250 mg/mL (561.27 mM; 超声助溶 )

OC(=O)\C=C/C(O)=O.OC(=O)\C=C/C(O)=O.C1CN(CCN1)c1ccc2ccccc2n1

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(-20℃)

With Ice Pack

≥ 2 years