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Pamoic acid disodium
CAS No. 6640-22-8
Pamoic acid disodium ( —— )
产品货号. M33901 CAS No. 6640-22-8
Pamoic acid disodium 是一种有效的 GPR35 激动剂，EC50 值为 79 nM。Pamoic acid disodium 诱导 GPR35 内在化并激活 ERK1/2，EC50 值分别为 22 nM 和 65 nM。Pamoic acid disodium 有效地将 β-arrestin2 募集到 GPR35，并具有抗伤害感受的作用。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
|
| 1G | ￥97 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥212 | 有现货 |
|
生物学信息
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产品名称Pamoic acid disodium
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Pamoic acid disodium 是一种有效的 GPR35 激动剂，EC50 值为 79 nM。Pamoic acid disodium 诱导 GPR35 内在化并激活 ERK1/2，EC50 值分别为 22 nM 和 65 nM。Pamoic acid disodium 有效地将 β-arrestin2 募集到 GPR35，并具有抗伤害感受的作用。
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产品描述Pamoic acid disodium is a potent GPR35 agonist with an EC50 value of 79 nM. Pamoic acid disodium induces GPR35 internalization and activates ERK1/2 with EC50 values of 22 nM and 65 nM, respectively. Pamoic acid disodium potently recruits β-arrestin2 to GPR35 and has an antinociceptive effect.
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体外实验Western Blot AnalysisCell Line:U2OS cells Concentration:1, 10, 100 nM and 1, 10 μM Incubation Time:15 min Result:A concentration-dependent activation of ERK1/2 was observed with an EC50 of 65 nM.
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体内实验Animal Model:Swiss-Webster mice (30–35 g)Dosage:25, 50, and 100 mg/kg Administration:Subcutaneous injection, once Result:Elicited dose-related antinociception, the dose causing 50% antinociception being 40.5 mg/kg.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number6640-22-8
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分子量411.36
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分子式C23H16NaO6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (231.30 mM; 超声助溶 (<60°C)
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SMILES[Na+].[Na+].Oc1c(cc2ccccc2c1Cc1c(O)c(cc2ccccc12)C([O-])=O)C([O-])=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Pingwei Zhao, et al. Targeting of the orphan receptor GPR35 by pamoic acid: a potent activator of extracellular signal-regulated kinase and β-arrestin2 with antinociceptive activity. Mol Pharmacol. 2010 Oct;78(4):560-8.?
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