N-Arachidonylglycine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-Arachidonylglycine (NA-Gly) 是内源性大麻素类 anandamide (AEA) 的羧基类似物，是一种 GPR18 激动剂 (EC50 = 44.5 nM)。与 AEA 不同，N-Arachidonylglycine 在 CB1 和 CB2 受体上均无活性。N-Arachidonylglycine 可抑制 GLYT2 (IC50 = 5.1 μM)。 N-Arachidonylglycine 也是子宫内膜细胞迁移的有效激活剂。

N-Arachidonylglycine (NA-Gly), a carboxylic analog of the endocannabinoid anandamide (AEA), is a GPR18 agonist (EC50 = 44.5 nM). Unlike AEA, N-Arachidonylglycine has no activity at either CB1 or CB2 receptors. N-Arachidonylglycine inhibits GLYT2 (IC50 = 5.1 μM). N-Arachidonylglycine also is an effective activator of endometrial cell migration.

N-Arachidonylglycine (0.1 nM-100 μM; 5 min) drives MAPK activation in GPR18-transfected HEK293 cells.N-Arachidonylglycine shows no activity at GLYT1 or GAT1 at concentrations up to 100 μm.Western Blot Analysis Cell Line:HEK293-GPR18 cells Concentration:0.1 nM-100 μM Incubation Time:5 minResult:Drove MAPK activation.

N-Arachidonylglycine (10 mg/kg; oral) increases blood concentrations of anandamide 9-fold.N-Arachidonylglycine (1.2 mg/kg; oral; once) results in a significant 70% reduction of peritoneal cells.Animal Model:Rats Dosage:10 mg/kg Administration:Oral Result:Inhibition of FAAH, causing a reduction in the hydrolytic cleavage of anandamid.Animal Model:Mouse (peritonitis model)Dosage:1.2 mg/kg Administration:Oral; once Result:Resulted in a significant 70% reduction of peritoneal cells.

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Others

Antioxidant

Antioxidant

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179113-91-8

361.52

C22H35NO3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (276.61 mM; 超声助溶 (<60°C) Ethanol 中的溶解度 : 50 mg/mL (138.30 mM; 超声助溶)

CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)NCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years