ML 10302 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML 10302 hydrochloride 是一种高效、选择性的 5-HT4 受体 (5-HT4 receptor) 激动剂，其 EC50 值为 4 nM。ML 10302 hydrochloride 对 5-HT4 的选择性结合作用比 5-HT3 至少高出 680 倍。

ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.

ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.

ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg Administration:Subcutaneous injection Result:Significantly increased sAPPα level in the cortex.

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GPCR/G Protein

5-HT Receptor

5-HT Receptor

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186826-17-5

349.25

C15H22Cl2N2O3

>98% (HPLC)

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COC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl

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(-20℃)

With Ice Pack

≥ 2 years