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ML 10302 hydrochloride
CAS No. 186826-17-5
ML 10302 hydrochloride ( —— )
产品货号. M33888 CAS No. 186826-17-5
ML 10302 hydrochloride 是一种高效、选择性的 5-HT4 受体 (5-HT4 receptor) 激动剂，其 EC50 值为 4 nM。ML 10302 hydrochloride 对 5-HT4 的选择性结合作用比 5-HT3 至少高出 680 倍。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥638 | 有现货 |
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| 10MG | ￥787 | 有现货 |
|
| 25MG | ￥1758 | 有现货 |
|
| 50MG | ￥2576 | 有现货 |
|
| 100MG | ￥3555 | 有现货 |
|
| 200MG | ￥4842 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称ML 10302 hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述ML 10302 hydrochloride 是一种高效、选择性的 5-HT4 受体 (5-HT4 receptor) 激动剂，其 EC50 值为 4 nM。ML 10302 hydrochloride 对 5-HT4 的选择性结合作用比 5-HT3 至少高出 680 倍。
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产品描述ML 10302 hydrochloride is a potent and selective 5-HT4 receptor agonist, with an EC50 of 4 nM. ML 10302 hydrochloride displays more than 680-fold selectivity over 5-HT3 receptor in binding assay.
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体外实验ML 10302 hydrochloride shows Kis of 1.07 nM and 782 nM for 5-HT4 receptor and 5-HT3 receptor, respectively, in binding assay.
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体内实验ML 10302 hydrochloride (20?mg/kg; s.c.) induces the soluble form of amyloid precursor protein (sAPPα) production in the cortex of mice.Animal Model:8-weeks old adult male C57BL/6j wild-type mice (23-27?g)Dosage:5 mg/kg, 10 mg/kg, 20?mg/kg Administration:Subcutaneous injection Result:Significantly increased sAPPα level in the cortex.
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同义词——
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通路GPCR/G Protein
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靶点5-HT Receptor
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受体5-HT Receptor
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研究领域——
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适应症——
化学信息
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CAS Number186826-17-5
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分子量349.25
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分子式C15H22Cl2N2O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCOC1=CC(=C(C=C1C(=O)OCCN2CCCCC2)Cl)N.Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Langlois, M., et al. Design of a potent 5-HT4 receptor agonist with nanomolar affinity. Bioorganic & Medicinal Chemistry Letters. 1994. 4(12), 1433–1436.
产品手册
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