Sarecycline hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sarecycline hydrochloride 是一种口服有效的窄谱四环素衍生物类抗生素。Sarecycline hydrochloride 具有抗炎活性。Sarecycline hydrochloride 能够抑制革兰氏阳性细菌和多种痤疮角质杆菌的活性。Sarecycline hydrochloride 干扰 tRNA 调节并将 mRNA 与 70S 核糖体结合。Sarecycline hydrochloride 能够用于中重度痤疮的研究 。

Sarecycline hydrochloride is an orally active narrow-spectrum tetracycline derivative antibiotic. Sarecycline hydrochloridehas anti-inflammatory activity. Sarecycline hydrochloride inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline hydrochloride interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline hydrochloride can be used to study moderate to severe acne .

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Animal Model:Female SD-1 mice (A murine neutropenic thigh wound infection model)Dosage:0.33, 1, 3, or 9?mg/kg Administration:Intravenously Result:Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32?mg/kg, respectively.Animal Model:Carrageenan-induced footpad edema male Sprague Dawley rats model Dosage:1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg Administration:Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw. Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.

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GPCR/G Protein

Antibacterial

Antibacterial

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1035979-44-2

523.96

C24H30ClN3O8

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (190.85 mM; 超声助溶 )

O[C@]12[C@]([C@H](N(C)C)C(O)=C(C(N)=O)C1=O)(C[C@]3(C(=C2O)C(=O)C=4C(C3)=C(CN(OC)C)C=CC4O)[H])[H].Cl

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(-20℃)

With Ice Pack

≥ 2 years