Oxatomide ( —— )

产品货号. M33637 CAS No. 60607-34-3

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Oxatomide
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Oxatomide 是一种有效的具有口服活性的双重 H1 组胺受体 (H1-histamine receptor) 和 P2X7 受体拮抗剂，具有抗组胺和抗过敏活性。Oxatomide 几乎完全阻断人 P2X7 受体中 ATP 诱导的电流 (IC50 为 0.95 μM)。Oxatomide 可抑制 ATP 诱导的 Ca2+ 内流，IC50 值为 0.43 μM，并且还抑制 5-羟色胺 (serotonin)。
产品描述

Oxatomide is a potent and orally active dual H1-histamine receptor and P2X7 receptor antagonist with antihistamine and anti-allergic activity. Oxatomide almost completely blocks the ATP-induced current in human P2X7 receptors (IC50 of 0.95 μM). Oxatomide inhibits ATP-induced Ca2+ influx with an IC50 value of 0.43 μM and also inhibits serotonin.
体外实验

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体内实验

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同义词

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通路

GPCR/G Protein
靶点

5-HT Receptor
受体

5-HT Receptor | Calcium Channel | P2X Receptor | Histamine Receptor
研究领域

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适应症

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1.Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51.?

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