5-Ethynyl-2-deoxyuridine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

5-Ethynyl-2'-deoxyuridine (EdU) 是一种胸腺嘧啶核苷类似物，在细胞增殖时能够插入正在复制的 DNA 分子中， EdU 与染料的共轭反应可以进行高效快速的细胞增殖检测分析。5-Ethynyl-2'-deoxyuridine 是一种 PROTAC linker，属于 alkyl chain 类。可用于合成 PROTAC 分子。5-Ethynyl-2'-deoxyuridine 是一种点击化学试剂。它含有 Alkyne 基团，可以和含有 Azide 基团的分子发生铜催化的叠氮-炔环加成反应 (CuAAc)。

5-Ethynyl-2'-deoxyuridine (EdU), a thymidine analogue, is incorporated into cellular DNA during DNA replication and the subsequent reaction of EdU with a fluorescent azide in a “Click” reaction. EdU staining is a fast, sensitive and reproducible method to study cell proliferation. 5-Ethynyl-2'-deoxyuridine is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. 5-Ethynyl-2'-deoxyuridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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Animal Model:Two month old female miceDosage:10, 20, 50, 100 or 200 mg/kg Administration:Single injection; intraperitoneally; 4 hours after EdU injection, brains were processed for EdU staining.Result:EdU positive cell numbers slightly increased in a dose-dependent manner both in control and running mice.

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PROTACs

PROTAC

PROTAC Linker

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61135-33-9

252.22

C11H12N2O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (198.24 mM; 超声助溶 ) H2O 中的溶解度 : 25 mg/mL (99.12 mM; 超声助溶)

OC[C@H]1O[C@H](C[C@@H]1O)n1cc(C#C)c(=O)[nH]c1=O

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(-20℃)

With Ice Pack

≥ 2 years