Rosabulin

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Rosabulin (STA 5312) 是一种有效的具有口服活性的微管 (microtubule) 抑制剂，可抑制微管组装。Rosabulin 具有广谱抗肿瘤活性。

Rosabulin (STA 5312) is a potent and orally active microtubule inhibitor that inhibits microtubule assembly. Rosabulin has broad-spectrum anti-tumor activity.

Rosabulin (STA 5312) demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, including hematologic and solid tumor cell lines of various origins (e.g. leukemia, lymphoma, breast, colon, uterine), with IC50 values extending down into the nanomolar range. Cell lines with multi-drug resistant (MDR) phenotypes are similarly sensitive to Rosabulin. The mechanism of action for Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle.

When dosed orally or intravenously, Rosabulin (STA 5312) has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors.

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Others

Other Targets

Microtubule Associated

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501948-05-6

400.45

C22H16N4O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 50 mg/mL (124.86 mM; 超声助溶 )

Cc1cc(NC(=O)C(=O)c2cc(Cc3ccc(cc3)C#N)n3ccccc23)sn1

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(-20℃)

With Ice Pack

≥ 2 years