Org41841

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ORG41841 是促黄体激素/绒毛膜促性腺激素受体 (LHCGR) 和促甲状腺激素受体 (TSHR) 的部分激动剂，其 EC50 值分别为 0.2 和 7.7 μM。

Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively.

Functional assays demonstrate that Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. Treatment of L570F with Org41841 reveals an improved EC50 of 800 nM. M9 responds to Org41841 with an improved EC50 of 2700 nM and a greatly improved efficacy for signaling to 99% of the maximal value observed for thyroid-stimulating hormone (TSH) stimulation of thyroid-stimulating hormone receptor (TSHR).

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Others

Other Targets

TSH Receptor

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301847-37-0

402.53

C19H22N4O2S2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (248.43 mM; 超声助溶 )

COc1cccc(c1)-c1nc(SC)nc2sc(C(=O)NC(C)(C)C)c(N)c12

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(-20℃)

With Ice Pack

≥ 2 years