Neuropathiazol

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Neuropathiazol 是一种神经元分化诱导物，能选择性地诱导多能海马神经祖细胞神经元分化。

Neuropathiazol, a neuronal differentiation inducer, selectively induces neuronal differentiation of multipotent hippocampal neural progenitor cells.

Neuropathiazol (5-15 μM; 5 hours) significantly slows cell proliferation without visible cytotoxic effects.Neuropathiazol (10 μM; 1-4 days) down-regulates Sox2 (a neural progenitor marker) and up-regulates NeuroD1 (a neuronal cell marker). Neuropathiazol also inhibits astroglial differentiation that is induced by LIF and BMP2.Neuropathiazol induces neuronal differentiation of multipotent adult hippocampal neural progenitor cells.Neuropathiazol can competitively suppress astrogliogenesis by LIF/BMP2/FBS in a dose-dependent manner.Cell Proliferation Assay Cell Line:HCN cells Concentration:5 μM, 10 μM, 15 μM Incubation Time:5 hours Result:Inhibited proliferation of HCN neural progenitor cells.RT-PCR Cell Line:HCN cells Concentration:10 μM Incubation Time:1 day, 4 days Result:Downregulated Sox2 and upregulated NeuroD1.

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Others

Other Targets

Others

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880090-88-0

338.42

C19H18N2O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (98.49 mM; 超声助溶 )

CCOC(=O)C1=CC=C(C=C1)N(C)C1=CSC(=N1)C1=CC=CC=C1

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(-20℃)

With Ice Pack

≥ 2 years