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Lidorestat
CAS No. 245116-90-9
Lidorestat ( —— )
产品货号. M33408 CAS No. 245116-90-9
Lidorestat (IDD-676) 是一种有效的，选择性的，口服活性的醛糖还原酶 (aldose reductase) 抑制剂，IC50 为 5 nM。Lidorestat 可用于慢性糖尿病并发症。Lidorestat 还可改善神经传导并减少白内障形成。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥373 | 有现货 |
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| 10MG | ￥598 | 有现货 |
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| 25MG | ￥1014 | 有现货 |
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| 50MG | ￥1535 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥432 | 有现货 |
|
生物学信息
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产品名称Lidorestat
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Lidorestat (IDD-676) 是一种有效的，选择性的，口服活性的醛糖还原酶 (aldose reductase) 抑制剂，IC50 为 5 nM。Lidorestat 可用于慢性糖尿病并发症。Lidorestat 还可改善神经传导并减少白内障形成。
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产品描述Lidorestat (IDD-676) is a potent, selective and orally active aldose reductase inhibitor with an IC50 of 5 nM. Lidorestat can be used for chronic diabetes complications. Lidorestat also improves nerve conduction and reduces cataract formation.
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体外实验From in vitro experiments, Lidorestat has a reported IC50 against recombinant human aldose reductase (/h/-ALR2) of 5 μM. Against recombinant human aldehyde reductase (/h/-ALR1), Lidorestat has a reported IC50 of 27,000 μM, yielding a selectivity of /h/-ALR1//h/-ALR2 of 5400:1.
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体内实验Lidorestat (25 mg/kg/day; oral administration; twice daily; for 6 weeks; diabetic mice) treatment decreases fructose and reduces mortality in diabetic hAR-expressing mice. And Lidorestat does not affect weight.Animal Model:Diabeticlow-density lipoprotein (LDL) receptor-deficient [Ldlr(-/-)] mice Dosage:25 mg/kg/day Administration:Oral administration; twice daily; for 6 weeks Result: Diabetic hAR-expressing mice had decreased fructose and reduced mortality.
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同义词——
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通路Endocrinology/Hormones
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靶点Reductase
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受体Reductase
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研究领域——
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适应症——
化学信息
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CAS Number245116-90-9
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分子量376.35
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分子式C18H11F3N2O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (132.86 mM; 超声助溶 (<60°C)
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SMILESOC(=O)Cn1cc(Cc2nc3c(F)c(F)cc(F)c3s2)c2ccccc12
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Noh HL, et al. Regulation of plasma fructose and mortality in mice by the aldose reductase inhibitor lidorestat. J Pharmacol Exp Ther. 2009 Feb;328(2):496-503.?
产品手册
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