Latanoprost acid

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Latanoprost acid 是前列腺素 (PG) F2α 的类似物，是选择性的前列腺素受体 FP 激动剂，FP 可以特异性激活 FP-PG 受体。Latanoprost acid 通过抑制 ERK，AKT，JNK 和 p38 级联反应，继而沿 c-fos/NFATc1 通路抑制 RANKL 诱导的破骨细胞生成和功能。Latanoprost acid 是一种可降低眼内压力的活性分子。

Latanoprost acid, an analog of prostaglandin (PG) F2α, is an selective prostanoid receptor (FP) agonist that specifically activates the FP-PG receptor. Latanoprost acid inhibits RANKL-induced osteoclastgenesis and function by inhibiting ERK, AKT, JNK, and p38 cascade, following by the c-fos/NFATc1 pathway. Latanoprost acid is a medication which works to lower pressure inside the eyes.

Latanoprost acid (10-20 μM;24 hours) reduces he protein expressions of c-fos and NFATc1. Latanoprost acid (10μM with 50ng/ml RANKL) significantly inhibits ERK, p38, AKT and JNK. Latanoprost acid (10 μM, 20 μM) significantly inhibits the mature osteoclast formation. Western Blot Analysis Cell Line:Bone marrow-derived macrophages cells (BMMs) Concentration:10 μM, 20 μM Incubation Time:24 hours Result:Reduced he protein expressions of c-fos and NFATc1.

Latanoprost acid (i.p.; 20 mg/kg; once a day for 7 days) notably prevents LPS-induced bone destruction at a dose of 20mg/kg. Animal Model:8-week-old C57BL/6J mice Dosage:20 mg/kg Administration: Intraperitoneally injected; once a day for 7 days Result:Notably prevented LPS-induced bone destruction at a dose of 20mg/kg.

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Cell Cycle/DNA Damage

GPR

GPR

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41639-83-2

390.51

C23H34O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (256.08 mM; 超声助溶 )

O[C@H](CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O)CCc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years