Gemcitabine elaidate hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Gemcitabine elaidate (CP-4126) hydrochloride 是 Gemcitabine 的亲脂性前体。Gemcitabine elaidate hydrochloride 通过酯酶转化为 Gemcitabine 以被磷酸化。Gemcitabine elaidate hydrochloride 具有抗肿瘤活性。

Gemcitabine elaidate (CP-4126) hydrochloride is lipophilic pro-agent of Gemcitabine. Gemcitabine elaidate hydrochloride is converted to Gemcitabine by esterases in order to be phosphorylated.Gemcitabine elaidate hydrochloride exhibits anti-tumor activity.

Cell Cycle AnalysisCell Line:A549 and WiDR cells Concentration:0.0005, 0.001, 0.005, 0.01, 0.05, 0.1, 0.5, 1.0 μM Incubation Time:72 h Result:Induced a G2/M and S phase accumulation.

Animal Model:Female BALB/c nude (nu/nu) mice (5-8 weeks; 20-27 g) were bearing tumor of EKVX, H-146, MHMX, TAX II-1, OHS, THX, MA-11, CRL-1435, PANC-1 and MiaPaCa-2, respectively Dosage:25-120 mg/kg Administration:I.p. every 3 days for 5 doses Result:Inhibited the growth of EKVX, MHMX, TAX II-1, THX, CRL-1435 and PANC-1, with T/C values of 7%, 1%, 30%, 7%, 9%, and 12%, respectively.

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Others

Other Targets

Others

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2918768-08-6

564.11

C27H44ClF2N3O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (177.27 mM; 超声助溶 )

O[C@@H](C(F)(F)[C@H](N1C(N=C(C=C1)N)=O)O2)[C@H]2COC(CCCCCCC/C=C/CCCCCCCC)=O.Cl

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(-20℃)

With Ice Pack

≥ 2 years