Diloxanide furoate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Diloxanide furoate 是二苯氧尼特的前体。Diloxanide furoate 是一种有效的具有口服活性的抗原虫制剂 (anti-protozoal agent)，可用于阿米巴病、轻度肠道阿米巴病或无症状包囊带菌感染的相关研究。

Diloxanide furoate is the proagent of Diloxanide. Diloxanide furoate is a potent and orally active anti-protozoal agent and can be used for the research of amebiasis, mild intestinal amebiasis or asymptomatic cyst carriers.

Diloxanide furoate (1.95-2.5 μg/ml) has potent activity against different strains of E. histolytica, it is against BYso (grown with bacteria), SFL3 (grown with Chrithidia sp.), and SFL3 (grown axenically) with MIC values of 2.5 μg/ml, 2.5 μg/ml and 1.95 μg/ml, respectively.

Diloxanide furoate (oral administraion; 75-200 mg/kg; 3 days; once daily) is effective at different dose of dayin weanling rats. At 200 mg/kg, 100% of the treated rats are cured and no amoebic lesions are observed in the caecum. Besides, 85%,77%, and 44.4% of the treated rats are cured at the dose 150 mg/kg, 100 mg/kg, and 75 mg/kg, respectively. The ED50 value is 77.9 mg/kg for this agent in rats.Animal Model:Weanling Wistar rats Dosage:200 mg/kg; 150 mg/kg; 100 mg/kg; 75 mg/kg Administration:Oral administraion; 75-200 mg/kg; 3 days; once daily Result:Was against intestinal (caecal) amoebiasis in rats.

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Microbiology/Virology

Parasite

Parasite

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3736-81-0

328.15

C14H11Cl2NO4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 50 mg/mL (152.37 mM)

O=C(OC1=CC=C(C=C1)N(C(=O)C(Cl)Cl)C)C=2OC=CC2

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(-20℃)

With Ice Pack

≥ 2 years