Centrinone-B ( —— )

产品货号. M33313 CAS No. 1798871-31-4

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

产品询价大包装询价加入购物车

产品名称

Centrinone-B
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Centrinone-B (LCR-323) 是一种有效的，高度选择性的 PLK4 抑制剂，Ki 值为 0.59 nM。
产品描述

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM.
体外实验

Centrinone-B (LCR-323) is a potent and highly selective PLK4 inhibitor, with a Ki of 0.59 nM. Centrinone-B slightly binds to Aurora A and Aurora B, with Kis of 1239 nM and 5597.14 nM. Centrinone-B (LCR-323) exhibits >1000-fold selectivity for Plk4 over Aurora A/B in vitro and does not affect cellular Aurora A or B substrate phosphorylation at concentrations that deplete centrosomes. Centrinone-B (LCR-323) (0-200 nM) significantly decreases cell viability of PLK4-centriole conjunction melanoma cell lines except p53 mutant SK-MEL-28, and this effect is via inhibition of PLK4. Inhibition of PLK4 by Centrinone-B (LCR-323) also induces apoptosis in human melanoma cell lines.
体内实验

——
同义词

——
通路

Cell Cycle/DNA Damage
靶点

PLK
受体

PLK
研究领域

——
适应症

——

CAS Number

1798871-31-4
分子量

631.67
分子式

C27H27F2N7O5S2
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (39.58 mM; 超声助溶 )
SMILES

COc1c(Nc2cc(C)[nH]n2)nc(Sc2ccc(cc2F)S(=O)(=O)Cc2cccc(c2F)[N+]([O-])=O)nc1N1CCCCC1
化学全称

——

1. Wong YL, et al. Cell biology. Reversible centriole depletion with an inhibitor of Polo-like kinase 4. Science. 2015 Jun 5;348(6239):1155-60.?

计算器

产品手册

关联产品

Ilexsaponin A1

Ilexsaponin A 通过抗凋亡途径对缺血再灌注引起的心肌损伤具有保护作用。
T521

T521 is a selective inhibitor of the PBD of Plk1 and shows no inhibitory effect on Plk2 and Plk3.
CFI-400945

CFI-400945 是一种有效的、选择性的、口服活性的 polo 样激酶 4（PLK4；Ki 值为 0.26 nM）抑制剂。