Butyrolactone 3

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Butyrolactone 3 (MB-3) 是一个组蛋白乙酰转移酶 Gcn5 的特异性小分子抑制剂 (IC50=100 μM)，与 Gcn5 酶高度亲和。Butyrolactone 3 对 CBP 的抑制作用较弱 (IC50=0.5 mM)。Butyrolactone 3 可用于癌症、代谢性疾病、自身免疫性疾病和神经系统疾病的研究。

Butyrolactone 3 (MB-3) is a specifical small-molecule inhibitor of the histone acetyltransferase Gcn5 (IC50=100 μM), which has a high affinity to the Gcn5 enzyme comparable to that of its natural substrate, histone H3. Butyrolactone 3 shows weak inhibitory on CBP (IC50=0.5 mM). Butyrolactone 3 can be used in studies of cancer, metabolic, autoimmune and neurological diseases.

Western Blot Analysis Cell Line:RCH-ACV Concentration:50, 100, 200 μM Incubation Time:16 h Result:Decreased the protein levels of E2A-PBX1 and E2A in a dose-dependent manner.Reduced Wnt16 and GCN5 protein levels.

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Chromatin/Epigenetic

Epigenetic Reader Domain

Epigenetic Reader Domain | Antibacterial

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778649-18-6

184.19

C9H12O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (542.92 mM; 超声助溶 )

CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years