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Azido-PEG4-hydrazide
CAS No. 2170240-96-5
Azido-PEG4-hydrazide ( —— )
产品货号. M33280 CAS No. 2170240-96-5
Azido-PEG4-hydrazide 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。Azido-PEG4-hydrazide 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥326 | 有现货 |
|
| 10MG | ￥471 | 有现货 |
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| 25MG | ￥761 | 有现货 |
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| 50MG | ￥1386 | 有现货 |
|
| 100MG | ￥2007 | 有现货 |
|
| 200MG | ￥2988 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Azido-PEG4-hydrazide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Azido-PEG4-hydrazide 是一种 PROTAC linker，属于 PEG 类。可用于合成 PROTAC 分子。Azido-PEG4-hydrazide 是一种点击化学试剂。它含有 Azide 基团，可以和含有 Alkyne 基团的分子发生铜催化的叠氮-炔环加成反应（CuAAc)。还可以和含有 DBCO 或 BCN 基团的分子发生菌株促进的炔-叠氮环加成反应 (SPAAC)。
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产品描述Azido-PEG4-hydrazide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-hydrazide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. Strain-promoted alkyne-azide cycloaddition (SPAAC) can also occur with molecules containing DBCO or BCN groups.
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体外实验PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体PROTACs
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研究领域——
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适应症——
化学信息
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CAS Number2170240-96-5
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分子量305.33
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分子式C11H23N5O5
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 100 mg/mL (327.51 mM; 超声助溶 )
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SMILES[N-]=[N+]=NCCOCCOCCOCCOCCC(=O)NN
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Methylmalonic acid
甲基丙二酸 (MMA) 是一种二羧酸，可衍生自甲基丙二酰辅酶 A。它是癌症中维生素 B-12 缺乏的指标。
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(±)8(9)-EpETE
Eicosapentaenoic acid is converted to epoxyeicosatetraenoic acids (EpETEs) by several cytochrome P450 isoforms. The major product of this epoxygenase pathway, (±)17(18)-EpETE , relaxes vascular and airway smooth muscle by activating large conductance Ca2+-activated K+ (BKCa) channels by directly interacting with BKα channel subunits. (±)8(9)-EpETE is an epoxygenase pathway product produced from EPA by CYP450 both in vitro and in vivo. The biological actions and physiological effects of this epoxide remain to be determined.
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Mepyramine
Mepyramine is a histamine H1 antagonist. It has mild hypnotic properties and some local anesthetic action and is used for allergies both parenterally and locally.
