FKBP12 PROTAC RC32 ( —— )

产品货号. M33217 CAS No. 2375555-66-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

FKBP12 PROTAC RC32
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

FKBP12 PROTAC RC32 (RC32) 是基于 PROTAC 的有效 FKBP12 降解剂。FKBP12 PROTAC RC32 包含雷帕霉素 (Rapamycin；HY-10219) 和Cereblon E3 泛素连接酶配体 (Pomalidomide；HY-10984)。
产品描述

FKBP12 PROTAC RC32 (RC32) is a potent FKBP12 degrader based on PROTAC technology. FKBP12 PROTAC RC32 contains conjugation of Rapamycin (HY-10219) and a ligand for an Cereblon E3 ubiquitin ligase (Pomalidomide; HY-10984).
体外实验

Western Blot Analysis Cell Line:Jurkat cells Concentration:0.1, 1, 10, 100, 1000 nM Incubation Time:For 12?hours Result:Resulted in 50% protein degradation (DC50) of ~0.3?nM after only 12?h of treatment.
体内实验

Animal Model:Male and female mice Dosage:30?mg/kg Administration:IP; twice a day; 1 day Result:Degraded the FKBP12 protein in most of the organs of treated mice after only 1 day of treatment.
同义词

——
通路

Others
靶点

Other Targets
受体

PROTACs
研究领域

——
适应症

——

CAS Number

2375555-66-9
分子量

1426.69
分子式

C75H107N7O20
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 10 mg/mL (7.01 mM; 超声助溶 )
SMILES

O=C1NC(C(N2C(C(C=CC=C3NCCOCCOCCN4C=C(COCCO[C@H]5CC[C@@H](C[C@H]([C@](OC([C@@]6([H])N(C(C([C@]7(O)O[C@@]8([H])CC[C@H]7C)=O)=O)CCCC6)=O)([H])CC([C@@H](/C=C(C)\[C@@H](O)[C@@H](OC)C([C@H](C)C[C@H](C)/C=C\C=C\C=C(C)/[C@@H](OC)C8)=O)C)=O)C)C[C@H]5OC)N=N4)=C3C2=O)=O)CC1)=O
化学全称

——

1. A chemical approach for global protein knockdown from mice to non-human primates. Cell Discov. 2019 Feb 5;5:10.?

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