6-Aminochrysene

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

6-Aminochrysene (6-Aminochrysene) 是芳香胺类化合物，可用于脾肿大，骨髓性白血病和乳腺癌的研究。

6-Aminochrysene (6-Aminochrysene) is an aromatic amine used as a chemotherapeutic agent in the treatment of splenomegaly, myeloid leukemia, and breast cancer.

6-Aminochrysene inhibits the hydroxylation of aniline, 0-demethylation of p-nitroanisole, and N-demethylation of aminopyrine by rat liver microsomes. Pre-treatment of rats with 6-aminochrysene markedly decreases the N-demethylation in vitro but significantly increases the hydroxylation and the 0-demethylation.

6-Aminochrysene is an inhibitor of the growth of several solid experimental tumours in vivo and has a cancerostatic effect on human breast cancer. Long term topical skin application of 6-Aminochrysene to mice induces development of benign skin tumors after 3 months and of skin malignancies after 7 months. Female mice respond earlier than males. Induction of skin tumors is more rapid when 6-Aminochrysene is applied ventrally instead of dorsally. Urinary excretion is about twice as high after skin application than after oral administration.

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Others

Other Targets

Others

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2642-98-0

243.3

C18H13N

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (411.02 mM; 超声助溶 )

Nc1cc2c3ccccc3ccc2c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years