YLF-466D

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

YLF-466D 是一种新型 AMPK 激活剂，可抑制血小板聚集。

YLF-466D is a newly developed AMPK activator, which inhibits platelet aggregation.

The effect of YLF-466D on platelet AMPK and aggregation are examined to test whether YLF-466D can stimulate AMPK in platelets and thereby suppress aggregation. Platelet AMPK is activated by YLF-466D, which is confirmed with activation-dependent phosphorylation at Thr172. Consistent with this result, YLF-466D inhibits platelet aggregation induced by thrombin. Such inhibition is observed in the aggregation elicited by ADP and collagen as well as thrombin, indicating that the antiaggregatory effect of YLF-466D is not platelet-agonist specific but common, regardless of agonist type. All the effects on AMPK and aggregation are concentration-dependent with the highest efficacy at 150 μM. IC50 against thrombin-, ADP- and collagen-induced aggreation are approximately 84, 55 and 87 μM, respectively.

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Membrane Transporter/Ion Channel

AMPK

AMPK

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1273323-67-3

465.93

C29H20ClNO3

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (214.62 mM)

OC(=O)c1cccc(CN2C(=O)\C(=C(/c3ccccc3)c3ccc(Cl)cc3)c3ccccc23)c1

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(-20℃)

With Ice Pack

≥ 2 years