USP30 inhibitor 11

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

USP30 inhibitor 11 是一个选择性和有效的 USP30 抑制剂，IC50 值为 0.01 μΜ。USP30 inhibitor 11 是例 83，源于专利文献 WO2017009650A1，用于研究癌症和涉及线粒体功能障碍疾病。

USP30 inhibitor 11 is a selective and potent ubiquitin specific peptidase 30 (USP30) inhibitor with an IC50 of 0.01 μΜ, the example 83 extracted from patent WO2017009650A1. USP30 inhibitor 11 is used for the study of cancer and conditions involving mitochondrial dysfunction.

USP30 is a 517 amino acid protein which is found in the mitochondrial outer membrane. It is the sole deubiquitylating enzyme bearing a mitochondrial addressing signal and has been shown to deubiquitylate a number of mitochondrial proteins.USP30 inhibitor 11 (0.01-30 μΜ; λEx=540 nm; λEm=590 nm) inhibits USP30 biochemical activity with an IC50 of 0.01 μΜ in a USP30 biochemical IC50 assay.

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Proteasome/Ubiquitin

DUB

DUB

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2067332-64-1

368.41

C17H16N6O2S

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 33.33 mg/mL (90.47 mM; 超声助溶 )

COc1ccc(nc1C#N)-c1csc(n1)N(C)C(=O)[C@@H]1CCCN1C#N

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(-20℃)

With Ice Pack

≥ 2 years