Tubulin inhibitor 8

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Tubulin inhibitor 8 (Compound 33b) 是一种微管蛋白 (tubulin) 抑制剂，也是多种肿瘤细胞系的有效抑制剂。Tubulin inhibitor 8 抑制微管蛋白聚合，IC50 为 0.73 μM。Tubulin inhibitor 6 抑制 K562 细胞生长，IC50 为 14 nM。

Tubulin inhibitor 8 (Compound 33b) is a tubulin inhibitor and a potent inhibitor of multiple cancer cell lines. Tubulin inhibitor 8 inhibits tubulin polymerization with an IC50 of 0.73 μM. Tubulin inhibitor 8 inhibits K562 cell growth with an IC50 of 14 nM.

Tubulin inhibitor 8 blocks mitosis through an arrest of cells in the G2/M phase, as illustrated in typical histograms.Tubulin inhibitor 8 shows excellent antiproliferative potencies with IC50s of 15, 6, 8, 2, 8, 6, and 9 nM for NCIH460, SKOV3, BT549, 451LU, SW480, COLO-205, and DLD-1 tumor cell lines, recpectively.

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Others

Other Targets

Microtubule Associated

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1309925-39-0

342.35

C21H14N2O3

>98% (HPLC)

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C(=O)(N1C=2C(OC=3C1=CC=CC3)=CC(C#N)=CC2)C4=CC=C(OC)C=C4

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(-20℃)

With Ice Pack

≥ 2 years