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Synucleozid hydrochloride
CAS No. 2741856-68-6
Synucleozid hydrochloride ( —— )
产品货号. M33133 CAS No. 2741856-68-6
Synucleozid (NSC 377363) 是可编码 α-突触核蛋白的 SNCA?mRNA 的有效抑制剂。Synucleozid 选择性靶向?α-synuclein?mRNA 的 5'UTR的 IRE 位点，减少了加载到多核糖体中的?SNCA?mRNA 的量，从而抑制了α-synuclein 蛋白的翻译。Synucleozid 有潜力用于帕金森病的相关研究。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Synucleozid hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Synucleozid (NSC 377363) 是可编码 α-突触核蛋白的 SNCA?mRNA 的有效抑制剂。Synucleozid 选择性靶向?α-synuclein?mRNA 的 5'UTR的 IRE 位点，减少了加载到多核糖体中的?SNCA?mRNA 的量，从而抑制了α-synuclein 蛋白的翻译。Synucleozid 有潜力用于帕金森病的相关研究。
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产品描述Synucleozid hydrochloride (NSC 377363 hydrochloride) is a potent inhibitor of the?SNCA?mRNA?that encodes α-synuclein protein. Synucleozid selectively?targets the?α-synuclein?mRNA 5′ UTR at the designed IRE site, decreases the amount of?SNCA?mRNA loaded into polysomes and thereby inhibits?SNCA?translation. Synucleozid has the potential for the investigation of Parkinson’s disease.
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体外实验Synucleozid (0.25-1 μM; 24 hours) abrogates cytotoxicity induced by α-synuclein preformed fibrils, which act as seeds and recruit endogenous α-synuclein to aggregate.Synucleozid (0-1 μM; 24 hours) binds to the A bulge near the base of the IRE hairpin, reduced levels of α-synuclein in a dose-dependent manner with an IC50 of 500 nM, and inhibits α-synuclein protein expression in SH-SY5Y neuroblastoma cells.Synucleozid (100 nM-100 μM; 24 hours) binds to 2-AP-labeled and native IRE RNA with similar affinities. It decreases 2-AP emission with an EC50?value of 2.7 ± 0.4 μM, recovery of 2-AP emissions is observed as a function of unlabeled?SNCA?IRE RNA (RNA-0) concentration, affording a competitive?Kd?of 1.5 ± 0.3 μM.Synucleozid (0.25-1 μM; 24 hours) decreases α-synuclein and other proteins that have IREs in their mRNA’s UTR including APP, PrP, Ferritin and TfR as a dose-dependent mannner. All panels is completed in SH-SY5Y cells, except for PrP protein which is assessed in Neuro-2A cells.Cell Viability Assay Cell Line:SH-SY5Y neuroblastoma cells Concentration:0.25 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Decreased LDH release as a dose-dependent manner.Western Blot Analysis Cell Line:SH-SY5Y neuroblastoma cells Concentration:0.25 μM, 0.5 μM, 1 μM Incubation Time:24 hours Result:Decreased α-synuclein expression as a concentration-dependent manner.
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体内实验——
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同义词——
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通路Cell Cycle/DNA Damage
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靶点DNA/RNA Synthesis
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受体DNA/RNA Synthesis
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研究领域——
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适应症——
化学信息
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CAS Number2741856-68-6
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分子量404.9
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分子式C22H21ClN6
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 125 mg/mL (308.72 mM; 超声助溶 ) H2O 中的溶解度 : 2 mg/mL (4.94 mM; 超声助溶)
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SMILESCl.N=C(N)C1=CC=C(C=C1)NC=2C=CC(=CC2)C3=CC4=CC=C(C=C4N3)C(=N)N
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Zhang P, et al. Translation of the intrinsically disordered protein α-synuclein is inhibited by a small molecule targeting its structured mRNA.Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1457-1467.?
产品手册
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