021-51111890
购物车（）
sales@molnova.cn
Pronetalol
CAS No. 54-80-8
Pronetalol ( —— )
产品货号. M33103 CAS No. 54-80-8
Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常，也可以限制脑动静脉畸形 (AVMs)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥245 | 有现货 |
|
| 5MG | ￥392 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥432 | 有现货 |
|
生物学信息
-
产品名称Pronetalol
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常，也可以限制脑动静脉畸形 (AVMs)。
-
产品描述Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias and limits the cerebral arteriovenous malformation (AVMs).
-
体外实验Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment.
-
体内实验Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Others
-
研究领域——
-
适应症——
化学信息
-
CAS Number54-80-8
-
分子量229.32
-
分子式C15H19NO
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO 中的溶解度 : 50 mg/mL (218.04 mM; 超声助溶 )
-
SMILESCC(C)NCC(O)c1ccc2ccccc2c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1. Aroesty JM, et al. The effects of a beta-adrenergic blocking agent, pronethalol, on digitalis-induced ventricular arrhythmias. Am Heart J. 1966 Apr;71(4):503-8.?
产品手册
关联产品
-
Dehydrodiconiferyl a...
Dehydrodiconiferyl alcohol (DHCA) is a lignan isolated from calabash that inhibits osteoclast differentiation and oophorectomy induced bone loss by acting as an estrogen receptor agonist.
-
4-Nitrophenyl α-D-ga...
4-硝基苯基 α-D-吡喃半乳糖苷 (PNP-α-D-Gal) 是 4-硝基苯基 (pNP) 吡喃葡萄糖苷的人工底物，用于检测 α-半乳糖苷酶活性。
-
1-Methyl-2-[(6Z,9Z)-...
Methyl-2-[(6Z,9Z)-6,9-pentadecadienyl]-4(1H)-quinolone9, a quinolone alkaloid derived from Evodia rutaecarpa, is a potent antagonist of the angiotensin II receptor, displaying an IC50 value of 48.2 μM.
