ML334

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ML334 (LH601A) 是一种有效的，细胞可渗透的 NRF2 激活剂，通过抑制 Keap1-NRF2 蛋白质相互作用来发挥作用。ML334 以 Kd 值为 1μM 来结合 Keap1 Kelch 域。ML334 刺激 NRF2 表达和核易位并诱导抗氧化反应元件 (ARE) 活性。

ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 μM. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity.

RT-PCR Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:6 hours, 16 hours Result:Increased NQO1 and TRX1 mRNAs between 2- and 3-fold at both 6 and 16 h. Enhanced HO-1 mRNA expression between 4- and 7-fold at 6 h.Western Blot Analysis Cell Line:HEK293 cells Concentration:50 μM or 100 μM Incubation Time:16 hours Result:Enhanced HO-1 and TRX1 protein expression at 16 h.

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Nuclear Receptor/Transcription Factor

Keap1-Nrf2

Nrf2

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1432500-66-7

446.49

C26H26N2O5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 44.65 mg/mL (100.00 mM; 超声助溶 ) Ethanol 中的溶解度 : 44.65 mg/mL (100.00 mM; 超声助溶)

OC(=O)[C@H]1CCCC[C@H]1C(=O)N1CCc2ccccc2[C@H]1CN1C(=O)c2ccccc2C1=O

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(-20℃)

With Ice Pack

≥ 2 years