K-80003

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

K-80003 有效抑制 tRXRα 依赖性的 Akt 激活和肿瘤细胞生长。

K-80003 is a potent inhibitor of tRXRα-dependent Akt activation and cancer cell growth.

When MCF-7 cells are cotreated with K-80003, TNFα-induced colocalization of tRXRα with p85α in the cytoplasm is inhibited, resulting in tRXRα nuclear localization. Western blotting shows that K-80003-stabilized tetrameric form of tRXRα is found exclusively in the nuclear fraction, while tRXRα monomer is distributed both in the nuclear and cytoplasmic fractions.

K-80003 is a potent inhibitor of AKT activation by all-trans-retinoic acid. K-80003 displays enhanced efficacy in inhibiting tRXRα-dependent AKT activation and tRXRα tumor growth in animals. K-80003 has high affinity to RXRα but lacks COX inhibitory activity.

——

Cytoskeleton/Cell Adhesion Molecules

Akt

RAR/RXR? | Akt

——

——

1292821-90-9

336.4

C22H21FO2

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 30 mg/mL (89.18 mM; 超声助溶 )

CC(C)c1ccc(\C=C2\C(C)=C(CC(O)=O)c3cc(F)ccc23)cc1

——

(-20℃)

With Ice Pack

≥ 2 years