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DO34
CAS No. 1848233-58-8
DO34 ( —— )
产品货号. M32892 CAS No. 1848233-58-8
DO34 是一个强效的、选择性的、具有中枢活性的二酰基甘油脂肪酶 (DAGL) 抑制剂，其对 DAGLα 转换的 IC50 值为 6 nM，对 DAGLβ 的IC50 值为 3-8 nM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1169 | 有现货 |
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| 10MG | ￥1767 | 有现货 |
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| 25MG | ￥3116 | 有现货 |
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| 50MG | ￥4418 | 有现货 |
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| 100MG | ￥5958 | 有现货 |
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| 200MG | ￥7938 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1378 | 有现货 |
|
生物学信息
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产品名称DO34
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述DO34 是一个强效的、选择性的、具有中枢活性的二酰基甘油脂肪酶 (DAGL) 抑制剂，其对 DAGLα 转换的 IC50 值为 6 nM，对 DAGLβ 的IC50 值为 3-8 nM。
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产品描述DO34 is a highly potent, selective and centrally active diacylglycerol lipase (DAGL) inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, and an IC50 for DAGLβ.
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体外实验DO34 is a highly potent, selective and centrally active DAGL inhibitor, with an IC50 of 6 nM for DAGLα conversion of SAG to 2-AG, as determined using a real-time, fluorescence-based natural substrate assay with membrane lysates from HEK293T cells expressing recombinant human DAGLα. It is also confirmed that and DO34 is a potent inhibitor of DAGLβ with IC50 of 3-8 nM.
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体内实验DO34 (compound 39) prevents fasting-induced refeeding of mice, which is typical cannabinoid CB1-receptor mediated behavior. DO34 (comound 39) reduces brain 2-AG levels in dose- and time dependent manner. DO34 could block the tonic CB1 activation. AM251 significantly increases basal PF-EPSCs in MAGL-TKO mice, and the effect of AM251 is blocked by the DAGL inhibitor DO34.
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同义词——
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通路Others
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靶点Other Targets
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受体Others
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研究领域——
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适应症——
化学信息
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CAS Number1848233-58-8
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分子量531.53
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分子式C26H28F3N5O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : ≥ 100 mg/mL (188.14 mM )
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SMILESO=C(OC(C)(C)C)N1CCN(C(=O)N2N=NC(=C2)C=3C=CC(OC(F)(F)F)=CC3)C(CC=4C=CC=CC4)C1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Ogasawara D, et al. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Proc Natl Acad Sci U S A. 2016 Jan 5;113(1):26-33.?
