Desformylflustrabromine hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Desformylflustrabromine hydrochloride 是一个有选择性的 α4β2 神经元烟碱乙酰胆碱受体 (nAChR) 激动剂，其 pEC50 值为 6.48。

Desformylflustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48.

Desformyl flustrabromine hydrochloride is a selective agonist of α4β2 neuronal nicotinic acetylcholine receptor (nAChR) with a pEC50 of 6.48. ACh-induced currents are potentiated and inhibited by Desformyl flustrabromine hydrochloride in the high sensitivity (HS) and low sensitivity (LS) isoform preparations, although Desformylflustrabromine hydrochloride displays a higher potency on the LS isoform(pEC50=6.4±0.2) compare with the HS isoform (pEC50=5.6±0.2). Desformyl flustrabromine hydrochloride potentiates ACh-induced responses of wild-type receptors expressed using the HS isoform preparation maximally by 350±20%, which is similar to receptors expressed via the LS isoform preparation (350±30%).

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Cell Cycle/DNA Damage

AChR

AChR

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951322-11-5

437.19

C17H12INO5

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : ≥ 105 mg/mL (293.53 mM) H2O 中的溶解度 : 5 mg/mL (13.98 mM; 超声助溶)

Cl.CNCCc1c([nH]c2cc(Br)ccc12)C(C)(C)C=C

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(-20℃)

With Ice Pack

≥ 2 years