CRA-026440 hydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CRA-026440 hydrochloride 是一种有效的广谱 HDAC (HDAC) 抑制剂。作用于 HDAC1，HDAC2，HDAC3，HDAC6，HDAC8 和 HDAC10 的 Ki 分别为 4 nM，14 nM，11 nM，15 nM，7 nM 和 20 nM。CRA-026440 hydrochloride 具有抗肿瘤和抗血管生成活性。

CRA-026440 hydrochloride is a potent, broad-spectrum HDAC (HDAC) inhibitor. The Ki values against recombinant HDAC isoenzymes HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10 are 4 nM, 14 nM, 11 nM, 15 nM, 7 nM, and 20 nM respectively. CRA-026440 hydrochloride shows antitumor and antiangiogenic activities. CRA-026440 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

Western Blot Analysis Cell Line:HCT116 cells Concentration:0.1 μM, 0.5 μM, 1 μM, 5 μM, 10 μM Incubation Time:18 hours Result:Resulted in the accumulation of both acetylated histones and acetylated tubulin. Induced expression of the cyclin-dependent kinase inhibitor p21Cip1/WAF1.

Animal Model:HCT-116 tumor-bearing nude mice Dosage:100 mg/kg Administration:i.v.; daily; for three consecutive days Result:Resulted in a statistically significant reduction in tumor growth.

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Cell Cycle/DNA Damage

HDAC

HDAC

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847459-98-7

456.92

C23H25ClN4O4

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (218.86 mM; 超声助溶 )

Cl.CN(C)CCOc1ccc2[nH]c(cc2c1)C(=O)NCC#Cc1ccc(cc1)C(=O)NO

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(-20℃)

With Ice Pack

≥ 2 years