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CO23
CAS No. 1370363-74-8
CO23 ( —— )
产品货号. M32851 CAS No. 1370363-74-8
CO23 是一种选择性的 TRα (甲状腺激素受体)激动剂，用于调节生长发育。CO23 能够通过血脑屏障转运。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥5472 | 有现货 |
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| 10MG | ￥7762 | 有现货 |
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| 25MG | ￥11067 | 有现货 |
|
| 50MG | ￥15159 | 有现货 |
|
| 100MG | ￥19620 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CO23
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CO23 是一种选择性的 TRα (甲状腺激素受体)激动剂，用于调节生长发育。CO23 能够通过血脑屏障转运。
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产品描述CO23 is a selective thyroid hormone receptor (TR) α agonist and used for growth and development regulation. CO23 was able to be transported through the blood-brain barrier.
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体外实验——
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体内实验CO23 (ip; 0.04-5.0 nmol/g) has ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses are equally effective. CO23 has no effect at the lowest dose of 0.04 nmol/g and increases Dio1 mRNA 5-, 10-, and 15-fold at the doses of 0.8, 2.5, and 5 nmol/g, respectively.Animal Model:Hypothyroid Wistar rats Dosage:0.04, 0.8, 2.5, and 5.0 nmol/g Administration:Ip Result:Had ≈50% cholesterol reduction with 0.8 nmol/g dose and higher doses were equally effective.
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同义词——
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通路Endocrinology/Hormones
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靶点THR
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受体Thyroid hormone receptor(THR)
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研究领域——
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适应症——
化学信息
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CAS Number1370363-74-8
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分子量592.17
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分子式C19H18I2N2O4
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO 中的溶解度 : 250 mg/mL (422.18 mM; 超声助溶 )
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SMILESCC(C)c1cc(Oc2c(I)cc(CC3NC(=O)NC3=O)cc2I)ccc1O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Grijota-Martínez C, et al. In vivo activity of the thyroid hormone receptor beta- and α-selective agonists GC-24 and CO23on rat liver, heart, and brain. Endocrinology. 2011 Mar;152(3):1136-42.?
