Abeprazan hydrochloride ( —— )

产品货号. M32767 CAS No. 1902954-87-3

Abeprazan (DWP14012) hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1093	有现货
10MG	￥1577	有现货
25MG	￥2399	有现货
50MG	￥3246	有现货
100MG	￥4167	有现货
200MG	￥5625	有现货
500MG	获取报价	有现货
1G	获取报价	有现货

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生物学信息

产品名称

Abeprazan hydrochloride
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Abeprazan (DWP14012) hydrochloride 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan hydrochloride 通过可逆的钾竞争性离子结合抑制 H+，K+- ATPase，而无需酸激活。Abeprazan hydrochloride 是一种潜在的质子泵抑制剂，用于研究与酸相关的疾病。
产品描述

Abeprazan hydrochloride (DWP14012 hydrochloride) is a potassium-competitive acid blocker. Abeprazan hydrochloride inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan hydrochloride is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases.
体外实验

The mechanism of action of Abeprazan hydrochloride is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation.
体内实验

Abeprazan hydrochloride (DWP14012 hydrochloride) inhibits acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion is equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models.
同义词

——
通路

Membrane Transporter/Ion Channel
靶点

Proton Pump
受体

Proton pump
研究领域

——
适应症

——

化学信息

CAS Number

1902954-87-3
分子量

446.87
分子式

C19H18ClF3N2O3S
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO 中的溶解度 : 25 mg/mL (55.94 mM; 超声助溶 )
SMILES

Cl.CNCc1cn(c(c1OC)-c1ccc(F)cc1F)S(=O)(=O)c1cccc(F)c1
化学全称

——

运输与储存

储存条件

(-20℃)
运输条件

With Ice Pack
稳定性

≥ 2 years

参考文献

1. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.?

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